abstract：:Combining multiple linear univariate features in one feature space and classifying the feature space using machine learning methods could predict epileptic seizures in patients suffering from refractory epilepsy. For each patient, a set of twenty-two linear univariate features were extracted from 6 electroencephalogra...

journal_title：Journal of neuroscience methods

authors： Rasekhi J,Mollaei MR,Bandarabadi M,Teixeira CA,Dourado A

更新日期：2013-07-15 00:00:00

abstract：:Neuronal loss in tissue surrounding an intracerebral hemorrhage (ICH) is usually quantified by labor-intensive histological methods that are subject to bias. Fluorescent protein expression has been successfully used as a marker of cell viability in vitro and in retinal studies in vivo, but not in any ICH model to date...

journal_title：Journal of neuroscience methods

authors： Chen-Roetling J,Lu X,Regan KA,Regan RF

更新日期：2013-06-15 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play an important role in the pathogenesis of ischaemic stroke. In particular, the mature forms of MMPs 2 and 9 have similar sizes and share gelatine as a common substrate. Both MMPs are upregulated in ischaemic stroke and play detrimental roles during stroke pathogenesis. Throughout t...

journal_title：Journal of neuroscience methods

authors： Alam M,Shuaib A

更新日期：2013-05-30 00:00:00

abstract：:Intrathecal (IT) administration is an important route of drug delivery, and its modelling in a large animal species is of critical value. Although domestic swine is the preferred species for preclinical pharmacology, no minimally invasive method has been established to deliver agents into the IT space. While a "blind"...

journal_title：Journal of neuroscience methods

authors： Pleticha J,Maus TP,Jeng-Singh C,Marsh MP,Al-Saiegh F,Christner JA,Lee KH,Beutler AS

更新日期：2013-05-30 00:00:00

abstract：:Research into therapeutics for neuropsychiatric disorders is increasingly focusing on drugs with new mechanisms of action, and such agents are often assessed in preclinical studies using nonhuman primates. However, researchers lack a standardised method to compare different drugs for common adverse effects on the nerv...

journal_title：Journal of neuroscience methods

authors： Uthayathas S,Shaffer CL,Menniti FS,Schmidt CJ,Papa SM

更新日期：2013-04-30 00:00:00

abstract：:Brain activity often consists of interactions between internal-or on-going-and external-or sensory-activity streams, resulting in complex, distributed patterns of neural activity. Investigation of such interactions could benefit from closed-loop experimental protocols in which one stream can be controlled depending on...

journal_title：Journal of neuroscience methods

authors： Rutishauser U,Kotowicz A,Laurent G

更新日期：2013-04-30 00:00:00

abstract：:Cytochrome oxidase (COX) is the enzyme that constitutes the last step of the mitochondrial electron transport chain for the production of ATP. Measurement of COX activity can be achieved by histochemistry, thus providing information about the metabolic status of the brain. Brain regions with high metabolism will prese...

journal_title：Journal of neuroscience methods

authors： Melendez-Ferro M,Rice MW,Roberts RC,Perez-Costas E

更新日期：2013-04-15 00:00:00

abstract：:One of the core symptoms of anxiety disorders, such as post-traumatic stress disorder, is the failure to overcome feelings of danger despite being in a safe environment. This deficit likely stems from an inability to fully process safety signals, which are cues in the environment that enable healthy individuals to ove...

journal_title：Journal of neuroscience methods

authors： Kazama AM,Schauder KB,McKinnon M,Bachevalier J,Davis M

更新日期：2013-04-15 00:00:00

abstract：UNLABELLED:Lobeline is a potential smoking cessation drug with affinity for the α4β2 nicotinic acetylcholine receptor and may inhibit the blood-brain barrier (BBB) amine transporter. The goal of this work was to use PET imaging to evaluate the effects of lobeline on the kinetic properties of [(18)F]nifene in the rat br...

journal_title：Journal of neuroscience methods

authors： Hillmer AT,Wooten DW,Farhoud M,Barnhart TE,Mukherjee J,Christian BT

更新日期：2013-04-15 00:00:00

abstract：:The most direct evaluation of human brain activity has been obtained from intracranial electrodes placed either on the surface of the brain or inserted into the brain to record from deep brain structures. Currently, the placement of intracranial electrodes implies transcranial surgery, either through a burr hole or a ...

journal_title：Journal of neuroscience methods

authors： Bower MR,Stead M,Van Gompel JJ,Bower RS,Sulc V,Asirvatham SJ,Worrell GA

更新日期：2013-03-30 00:00:00

abstract：:Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. LRRK2 kinase activity is required for toxicity in neuronal cell cultures suggesting that selective kinase inhibitors may prevent neurodegeneration in patients. Directly monitoring LRRK2 activity in cells would b...

journal_title：Journal of neuroscience methods

authors： Gillardon F,Kremmer E,Froehlich T,Ueffing M,Hengerer B,Gloeckner CJ

更新日期：2013-03-30 00:00:00

abstract：:We have developed a novel, low-cost device designed to monitor and modulate locomotor activity in murine subjects. This technology has immediate application to the study of effects of physical exercise on various neurobiological endpoints, and will also likely be useful in the study of psychomotor sensitization and dr...

journal_title：Journal of neuroscience methods

authors： Fantegrossi WE,Xiao WR,Zimmerman SM

更新日期：2013-01-30 00:00:00

abstract：:A microfluidic chip for culturing neurons and spatially isolating axons from somas is presented for use with visually guided whole-cell electrophysiological measurements. A modular design consisting of detachable and re-sealable layers is used to satisfy the requirements of both long-term neuron culturing as well as e...

journal_title：Journal of neuroscience methods

authors： Jokinen V,Sakha P,Suvanto P,Rivera C,Franssila S,Lauri SE,Huttunen HJ

更新日期：2013-01-30 00:00:00

abstract：:The interactions among cerebral regions involved in semantic word generations are explored through connectivity analysis based on fMRI data through multivariate autoregressive model (MVAR). Connections among the pars triangularis of the left inferior frontal gyrus (L45), the lateral fusiform girus (LFG) and the left m...

journal_title：Journal of neuroscience methods

authors： Bianchi AM,Marchetta E,Tana MG,Tettamanti M,Rizzo G

更新日期：2013-01-30 00:00:00

abstract：:We report on the modulation of respiratory sinus arrhythmia in rats with central pattern generator (CPG) hardware made of silicon neurons. The neurons are made to compete through mutually inhibitory synapses to provide timed electrical oscillations that stimulate the peripheral end of vagus nerve at specific points of...

journal_title：Journal of neuroscience methods

authors： Nogaret A,Zhao L,Moraes DJ,Paton JF

更新日期：2013-01-15 00:00:00

abstract：:Isotropic fractionation is a quantitative technique that allows reliable estimates of absolute numbers of neuronal and non-neuronal brain cells. However, being fast for single small brains, it requires a long time for processing large brains or many small ones, if done manually. To solve this problem, we developed a m...

journal_title：Journal of neuroscience methods

authors： Azevedo FA,Andrade-Moraes CH,Curado MR,Oliveira-Pinto AV,Guimarães DM,Szczupak D,Gomes BV,Alho AT,Polichiso L,Tampellini E,Lima L,de Lima DO,da Silva HA,Lent R

更新日期：2013-01-15 00:00:00

abstract：:Myo-inositol (mIns) is a marker of glial cells proliferation and has been shown to increase in early Alzheimer's disease (AD) pathology. mIns exhibits a concentration dependent chemical-exchange-saturation-transfer (CEST) effect (MICEST) between its hydroxyl groups and bulk water protons. Using the endogenous MICEST t...

journal_title：Journal of neuroscience methods

authors： Haris M,Singh A,Cai K,Nath K,Crescenzi R,Kogan F,Hariharan H,Reddy R

更新日期：2013-01-15 00:00:00

abstract：:In this study, a correlation matrix based hierarchical clustering (CMBHC) method is introduced to extract multiple correlation patterns from resting-state functional magnetic resonance imaging (fMRI) data. It was applied to spontaneous fMRI signals acquired from anesthetized rats, and the results were then compared wi...

journal_title：Journal of neuroscience methods

authors： Liu X,Zhu XH,Qiu P,Chen W

更新日期：2012-10-15 00:00:00

abstract：:Recent studies highlighted the disagreement between the typical number of neurons observed with extracellular recordings and the ones to be expected based on anatomical and physiological considerations. This disagreement has been mainly attributed to the presence of sparsely firing neurons. However, it is also possibl...

journal_title：Journal of neuroscience methods

authors： Pedreira C,Martinez J,Ison MJ,Quian Quiroga R

更新日期：2012-10-15 00:00:00

abstract：:Neural spike detection and classification, or spike sorting, is the first and a critical step prior to any single unit based neuroscientific studies and applications. A good spike sorter is usually characterized by high detection and classification accuracy, robust to changes in signal-to-noise ratio, objectivity in d...

journal_title：Journal of neuroscience methods

authors： Yuan Y,Yang C,Si J

更新日期：2012-09-30 00:00:00

abstract：:This paper overviews the design and implementation of three neuromorphic integrated circuits developed for the COLAMN ("Novel Computing Architecture for Cognitive Systems based on the Laminar Microcircuitry of the Neocortex") project. The circuits are implemented in a standard 0.35 μm CMOS technology and include spiki...

journal_title：Journal of neuroscience methods

authors： Wijekoon JH,Dudek P

更新日期：2012-09-15 00:00:00

abstract：:Experimental evidence points to the importance of mitochondrial transport defects in contributing to major neurodegenerative diseases, such as Parkinson's disease (PD). Studies of mitochondrial transport along single axons are difficult with traditional dissociated culture systems and the fragility of the midbrain dop...

journal_title：Journal of neuroscience methods

authors： Lu X,Kim-Han JS,O'Malley KL,Sakiyama-Elbert SE

更新日期：2012-07-30 00:00:00

abstract：:The FD Rapid GolgiStain Kit (FD NeuroTechnologies, Inc., Ellicott City, MD) was developed using an improved Golgi-Cox impregnation method to provide stable, sensitive, and convenient staining of mature neurons. However, embryonic neurons cannot be clearly visualized using this method. We have further improved the Golg...

journal_title：Journal of neuroscience methods

authors： Koyama Y,Tohyama M

更新日期：2012-07-30 00:00:00

abstract：:The event-related potential (ERP) and event-related field (ERF) techniques provide valuable insights into the time course of processes in the brain. Because neural signals are typically weak, researchers commonly filter the data to increase the signal-to-noise ratio. However, filtering may distort the data, leading to...

journal_title：Journal of neuroscience methods

authors： Acunzo DJ,Mackenzie G,van Rossum MC

更新日期：2012-07-30 00:00:00

abstract：:One of the hallmark pathologies associated with Alzheimer's disease (AD) is the conspicuous deposition of extracellular amyloid plaques within the forebrain. These plaques are primarily composed of fibrular aggregates of the A-beta peptide. Traditional methods for the histological localization of these plaques typical...

journal_title：Journal of neuroscience methods

authors： Schmued L,Raymick J,Tolleson W,Sarkar S,Zhang YH,Bell-Cohn A

更新日期：2012-07-30 00:00:00

abstract：:MicroRNAs (miRNAs) finely tune messenger RNA (mRNA) expression. As the brain is a highly heterogeneous tissue, physiologically relevant miRNA expression profiling greatly benefits from sampling brain regions or nuclei. MiRNA expression profiling from individual samples is also important for investigating potential dif...

journal_title：Journal of neuroscience methods

authors： Amar L,Benoit C,Beaumont G,Vacher CM,Crepin D,Taouis M,Baroin-Tourancheau A

更新日期：2012-07-30 00:00:00

abstract：:Analysis of cortical patterns requires accurate cortical surface registration. Many researchers map the cortical surface onto a unit sphere and perform registration of two images defined on the unit sphere. Here we have developed a novel registration framework for the cortical surface based on spherical thin-plate spl...

journal_title：Journal of neuroscience methods

authors： Park H,Park JS,Seong JK,Na DL,Lee JM

更新日期：2012-04-30 00:00:00

abstract：:A non-invasive integrated method was developed to measure neural and behavioural responses to peripheral sensory and noxious stimulation in human infants. The introduction of a novel event-detection interface allows synchronous recording of: (i) muscle and central nervous system activity with surface electromyography ...

journal_title：Journal of neuroscience methods

authors： Worley A,Fabrizi L,Boyd S,Slater R

更新日期：2012-04-15 00:00:00

abstract：:In this paper, a rule-based automatic sleep staging method was proposed. Twelve features including temporal and spectrum analyses of the EEG, EOG, and EMG signals were utilized. Normalization was applied to each feature to eliminating individual differences. A hierarchical decision tree with fourteen rules was constru...

journal_title：Journal of neuroscience methods

authors： Liang SF,Kuo CE,Hu YH,Cheng YS

更新日期：2012-03-30 00:00:00

abstract：:Bone morphogenetic protein 7 (BMP7), a member of the transforming growth factor β (TGF-β) superfamily, plays important roles in the development of various tissues and organs in mouse and human. In particular, BMP7 is critical for the formation of the nervous system and it is considered to have therapeutic potential in...

journal_title：Journal of neuroscience methods

authors： Chitty DW,Tremblay RG,Ribecco-Lutkiewicz M,Haukenfrers J,Zurakowski B,Massie B,Sikorska M,Bani-Yaghoub M

更新日期：2012-03-30 00:00:00

abstract：:We have recently reported that in the learned helplessness model of depression, the less hippocampal spine synapses rats have, the more helpless they become. It remains unclear, however, whether the observed synaptic changes are associated with the loss of CA1 pyramidal cells. Cell bodies in the CA1 pyramidal layer ar...

journal_title：Journal of neuroscience methods

authors： Miettinen R,Hajszan T,Riedel A,Szigeti-Buck K,Leranth C

更新日期：2012-03-30 00:00:00

abstract：:Triphasic electrical stimulation pulses with an adjustable phase amplitude ratio (PAR) can reduce stimulus artifacts in electrically evoked compound actions potentials (ECAPs) recording in the cochlea (see companion paper Bahmer and Baumann, submitted for publication). The present study describes the application of tr...

journal_title：Journal of neuroscience methods

authors： Bahmer A,Baumann U

更新日期：2012-03-30 00:00:00

abstract：:Corticomuscular coherence (CMC) estimation is a frequency domain method used to detect a linear coupling between rhythmic activity recorded from sensorimotor cortex (EEG or MEG) and the electromyogram (EMG) of active muscles. In motor neuroscience, rectification of the surface EMG is a common pre-processing step prior...

journal_title：Journal of neuroscience methods

authors： McClelland VM,Cvetkovic Z,Mills KR

更新日期：2012-03-30 00:00:00

abstract：:Functional magnetic resonance imaging allows precise localization of brain regions specialized for different perceptual and higher cognitive functions. However, targeting these deep brain structures for electrophysiology still remains a challenging task. Here, we propose a novel framework for MRI-stereotactic registra...

journal_title：Journal of neuroscience methods

authors： Ohayon S,Tsao DY

更新日期：2012-03-15 00:00:00

abstract：:The quantification of synapses in neuronal cultures is essential in studies of the molecular mechanisms underlying synaptogenesis and synaptic plasticity. Conventional counting of synapses based on morphological or immunocytochemical criteria is extremely work-intensive. We developed a fully automated method which qua...

journal_title：Journal of neuroscience methods

authors： Schätzle P,Wuttke R,Ziegler U,Sonderegger P

更新日期：2012-02-15 00:00:00

abstract：:Clonus can disrupt daily activities after spinal cord injury. Here an algorithm was developed to automatically detect contractions during clonus in 24h electromyographic (EMG) records. Filters were created by non-linearly scaling a Mother (Morlet) wavelet to envelope the EMG using different frequency bands. The envelo...

journal_title：Journal of neuroscience methods

authors： Mummidisetty CK,Bohórquez J,Thomas CK

更新日期：2012-02-15 00:00:00

abstract：:A variety of materials has been applied to neuronal cell culture substrates to improve the efficiency of the culture and to provide pertinent cell growth environment. Here we report the application of Parafilm(®) M ('Parafilm') as a novel substrate for neuronal culture and patterning. Cell culture results show that el...

journal_title：Journal of neuroscience methods

authors： Yoo SJ,Nam Y

更新日期：2012-02-15 00:00:00

abstract：BACKGROUND:In order to evaluate nerve regeneration in clinically relevant hindlimb surgical paradigms not feasible in fluorescent mice models, we developed a rat that expresses green fluorescent protein (GFP) in neural tissue. METHODS:Transgenic Sprague-Dawley rat lines were created using pronuclear injection of a tra...

journal_title：Journal of neuroscience methods

authors： Moore AM,Borschel GH,Santosa KB,Flagg ER,Tong AY,Kasukurthi R,Newton P,Yan Y,Hunter DA,Johnson PJ,Mackinnon SE

更新日期：2012-02-15 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is an X-chromosome-linked disorder that arises from a mutation in the gene for the cytoskeletal protein dystrophin, normally expressed in the myofibres. The most widely applied animal model in DMD basic research is the C57BL/10ScSn-mdx/J mouse, commonly referred to as the "mdx mouse"....

journal_title：Journal of neuroscience methods

authors： Klein SM,Vykoukal J,Lechler P,Zeitler K,Gehmert S,Schreml S,Alt E,Bogdahn U,Prantl L

更新日期：2012-01-30 00:00:00

abstract：INTRODUCTION:Transcranial magnetic stimulation (TMS) is used for assessing the excitability of cortical neurons and corticospinal pathways by determining the subject-specific motor threshold (MT). However, the MT is dependent on the TMS instrumentation and exhibits large variation. We hypothesized that between-subject ...

journal_title：Journal of neuroscience methods

authors： Danner N,Könönen M,Säisänen L,Laitinen R,Mervaala E,Julkunen P

更新日期：2012-01-30 00:00:00